Basic Information
| LncRNA/CircRNA Name | SNHG12 |
| Synonyms | small nucleolar RNA host gene 12 |
| Region | GRCh38_1:28578538-28582983 |
| Ensemble | ENSG00000197989 |
| Refseq | NR_024127 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | gastric cancer |
| ICD-0-3 | C16 |
| Methods | qRT-PCR, Microarray, Western blot assay |
| Sample | gastric epithelial cells (GES-1) and human GC cell lines (SGC-7901, HGC-27, BGC-823, MGC-803 and AGS),GEO,TCGA |
| Expression Pattern | up-regulated |
| Function Description | SNHG12 is overexpressed in GC tissues.higher SNHG12 expression was associated with a greater tumor invasion depth and poorer survival. In vitro, silencing SNHG12 suppressed GC cell proliferation, migration and invasion, but induced apoptosis and cell cycle arrest. Overexpressing SNHG12 had the opposite effects. In xenografted mice, knocking down SNHG12 reduced GC tumor growth. |
| Pubmed ID | 31808752 |
| Year | 2019 |
| Title | The Long Non-Coding RNA SNHG12 Promotes Gastric Cancer by Activating the Phosphatidylinositol 3-kinase/AKT Pathway |
External Links
| Links for SNHG12 | GenBank HGNC NONCODE |
| Links for gastric cancer | OMIM COSMIC |