Basic Information
| LncRNA/CircRNA Name | SNHG12 |
| Synonyms | small nucleolar RNA host gene 12 |
| Region | GRCh38_1:28578538-28582983 |
| Ensemble | ENSG00000197989 |
| Refseq | NR_024127 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | autophagy/apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | prostate cancer |
| ICD-0-3 | C61.9 |
| Methods | RT-qPCR, Dual luciferase reporter assay and RNA binding protein immunoprecipitation (RIP), Western blot |
| Sample | Peripheral venous blood samples,PCa cell lines, including 22RV1, Du145, LNCaP, MDaPCa2b, and a non-malignant cell line (RWPE1) |
| Expression Pattern | up-regulated |
| Function Description | SNHG12 expression was up-regulated in the serum of PCa patients as well as PCa cells. High expression of SNHG12 resulted in a poor prognosis of PCa patients. Moreover, suppression of SNHG12 inhibited viability and promoted apoptosis and autophagy of LNCaP cells. Furthermore, SNHG12 was found to act as a ceRNA to regulate the expression of Cyclin E1 (CCNE1) by sponging miR-195. Lastly, suppression of SNHG12 inhibited the activation of PI3K/AKT/mTOR pathway. |
| Pubmed ID | 31933941 |
| Year | 2019 |
| Title | Dysregulation of Long Non-Coding RNA SNHG12 Alters the Viability, Apoptosis, and Autophagy of Prostate Cancer Cells by Regulating miR-195/CCNE1 Axis |
External Links
| Links for SNHG12 | GenBank HGNC NONCODE |
| Links for prostate cancer | OMIM COSMIC |