Basic Information
| LncRNA/CircRNA Name | SNHG10 |
| Synonyms | NA |
| Region | NA |
| Ensemble | NA |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | Hepatocarcinogenesis |
| ICD-0-3 | NA |
| Methods | qRT-PCR, RIP, in vitro knockdown etc. |
| Sample | HCC tissues and adjacent normal tissues,cell lines(SNU-182, Huh-7, Hep3B, SK-Hep1 and SNU-387 ) |
| Expression Pattern | up-regulated |
| Function Description | SNHG10 expression positively correlated with SCARNA13 expression in 64 HCC cases, and high expression of SNHG10 or SCARNA13 was associated with poor overall survival. As SCARNA13 showed significant rise and decline after overexpression and knockdown of SNHG10, respectively, we hypothesized that SNHG10 might act as an upstream regulator of SCARNA13. SNHG10 and SCARNA13 coordinately contributed to the malignant phenotype of HCC cells, where SNHG10 served as a sponge for miR-150-5p and interacted with RPL4 mRNA to increase the expression and activity of c-Myb. |
| Pubmed ID | 31101763 |
| Year | 2019 |
| Title | LncRNA SNHG10 Facilitates Hepatocarcinogenesis and Metastasis by Modulating Its Homolog SCARNA13 via a Positive Feedback Loop |
External Links
| Links for SNHG10 | GenBank HGNC NONCODE |
| Links for Hepatocarcinogenesis | OMIM COSMIC |