Basic Information
| LncRNA/CircRNA Name | SNHG1 |
| Synonyms | SNHG1, LINC00057, NCRNA00057, U22HG, UHG, lncRNA16 |
| Region | GRCh38_11:62851988-62855914 |
| Ensemble | ENSG00000255717 |
| Refseq | NR_003098 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | cholangiocarcinoma |
| ICD-0-3 | NA |
| Methods | qPCR, RNA-seq, Microarray, RIP, ChIP, Western blot, Flow cytometry assay, |
| Sample | CCA cell lines (HuCCT, RBE). normal HIBEpiC. 92 pairs of cancer and 91 normal tissue samples. |
| Expression Pattern | up-regulated |
| Function Description | These data verified a major function of the epigenetic regulation of SNHG1 in CCA oncogenesis, in addition to its likely function as a target for CCA interruption.To summarize, as suggested by our research works, the regulatory mechanism in the tumorigenesis of SNHG1, by which SNHG1 could promote malignancy of CCA through regulating the transcription of CDKN1A epigenetically in the nucleus, facilitates cell survival and metastasis of CCA. SNHG1 epigenetically silenced CDKN1A transcription through EZH2-mediated H3K27me3 demethylation. |
| Pubmed ID | 29970899 |
| Year | 2018 |
| Title | Epigenetic silencing of tumor suppressor gene CDKN1A by oncogenic long non-coding RNA SNHG1 in cholangiocarcinoma. |
External Links
| Links for SNHG1 | GenBank HGNC NONCODE |
| Links for cholangiocarcinoma | OMIM COSMIC |