Basic Information
| LncRNA/CircRNA Name | SNHG1 |
| Synonyms | SNHG1, LINC00057, NCRNA00057, U22HG, UHG, lncRNA16 |
| Region | GRCh38_11:62851988-62855914 |
| Ensemble | ENSG00000255717 |
| Refseq | NR_003098 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | ovarian cancer |
| ICD-0-3 | C56.9 |
| Methods | qPCR, Western blot |
| Sample | epithelial ovarian carcinoma tissues, cell lines (IOSE25, CAOV-3, SKOV-3, ES2 and A2780) |
| Expression Pattern | up-regulated |
| Function Description | After lncRNA SNHG1 knockdown in SKOV-3 cells, the cell proliferation and clone formation abilities were significantly inhibited. inhibiting lncRNA SNHG1 could promote the apoptosis of SKOV-3 cells.the down-regulation of lncRNA SNHG1 could inhibit the invasion and metastasis of SKOV-3 cells, whose mechanism was related to the inhibition of EMT process and down-regulation of expressions of MMPs. |
| Pubmed ID | 29424921 |
| Year | 2018 |
| Title | Role of long non-coding RNA SNHG1 in occurrence and progression of ovarian carcinoma. |
External Links
| Links for SNHG1 | GenBank HGNC NONCODE |
| Links for ovarian cancer | OMIM COSMIC |