Basic Information
| LncRNA/CircRNA Name | SNHG1 |
| Synonyms | SNHG1, LINC00057, NCRNA00057, U22HG, UHG, lncRNA16 |
| Region | GRCh38_11:62851988-62855914 |
| Ensemble | ENSG00000255717 |
| Refseq | NR_003098 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | liver cancer |
| ICD-0-3 | C22.0 |
| Methods | qRT-PCR , Western blot , RIP , in vitro knockdown etc. |
| Sample | LC tissues and paracancerous tissues ,normal liver cell line (THLE-2) and LC cell lines (HepG, PLC, SMMC-7721, and SK-HEP-1) |
| Expression Pattern | up-regulated |
| Function Description | SNHG1 expression was higher in LC tissues than that of paracancerous tissues.SNHG1 was highly expressed in LC cells than that of normal liver cells.SNHG1 knockdown inhibited the proliferative and invasive abilities, and arrested the cell cycle in the G0/G1 phase of SMMC-7721 and SK-HEP-1 cells.SNHG1 could bind to DNMT1 and inhibit p53 expression. Overexpression of p53 partially reversed the inhibitory effects of SNHG1 on proliferative and invasive abilities of LC cells. |
| Pubmed ID | 31002127 |
| Year | 2019 |
| Title | LncRNA SNHG1 Promotes Liver Cancer Development Through Inhibiting p53 Expression via Binding to DNMT1 |
External Links
| Links for SNHG1 | GenBank HGNC NONCODE |
| Links for liver cancer | OMIM COSMIC |