Basic Information
| LncRNA/CircRNA Name | lncBRM |
| Synonyms | NA |
| Region | NA |
| Ensemble | NA |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | papillary thyroid cancer |
| ICD-0-3 | NA |
| Methods | qPCR, Western blot etc |
| Sample | PTC tissues,cell line(Nthy-ori 3-1, TPC-1 and SW1736) |
| Expression Pattern | up-regulated |
| Function Description | Reverse transcription-quantitative PCR assays revealed that lncBRM was upregulated in PTC tissues and cells. Cell Counting Kit-8, Transwell invasion and colony-formation assays were performed to assess cell proliferation, invasion and migration, respectively. Furthermore, high expression of lncBRM was associated with poor overall survival time in patients with PTC. lncBRM knockout significantly suppressed cell proliferation, migration and invasion. lncBRM was predicted to bind to microRNA (miR)-331-3p and targets SLC25A1. Overexpression of miR-331-3p or inhibition of SLC25A1 resulted in significantly suppressed proliferation, migration and invasion of PTC cells. |
| Pubmed ID | 32218861 |
| Year | 2020 |
| Title | Long Non-Coding RNA BRM Promotes Proliferation and Invasion of Papillary Thyroid Carcinoma by Regulating the microRNA-331-3p/SLC25A1 Axis |
External Links
| Links for lncBRM | GenBank HGNC NONCODE |
| Links for papillary thyroid cancer | OMIM COSMIC |