Basic Information
| LncRNA/CircRNA Name | SNHG1 |
| Synonyms | SNHG1, LINC00057, NCRNA00057, U22HG, UHG, lncRNA16 |
| Region | GRCh38_11:62851988-62855914 |
| Ensemble | ENSG00000255717 |
| Refseq | NR_003098 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | cholangiocarcinoma |
| ICD-0-3 | NA |
| Methods | RNA-seq, qPCR, Western blot, in vitro knockdown, RIP |
| Sample | cholangiocarcinoma tissues, cell lines (HuCCT1 and RBE) |
| Expression Pattern | up-regulated |
| Function Description | SNHG1 exhibited remarkable expression levels in carcinoma tissues when compared with adjacent tissues. SNHG1 knockdown extensively inhibited CCA cell migration as well as proliferation in vitro and in vivo. In addition, in accordance with the findings of the RNA-Seq analysis, SNHG1 knockdown exhibited a significant impact on the target genes that were linked to cell migration and regulation of cell proliferation, in addition to the apoptotic phenomenon. In a mechanistic manner, we also showed that SNHG1 bound to the histone methyltransferase enhancer of the zeste homolog 2 , which is an extremely conserved protein complex regulating gene expression with the help of methylating lysine 27 on histone H3), specifying the histone alteration pattern on the target genes, including CDKN1A, and, as a result, altered the CCA cell biology. |
| Pubmed ID | 29970899 |
| Year | 2018 |
| Title | Epigenetic Silencing of Tumor Suppressor Gene CDKN1A by Oncogenic Long Non-Coding RNA SNHG1 in Cholangiocarcinoma |
External Links
| Links for SNHG1 | GenBank HGNC NONCODE |
| Links for cholangiocarcinoma | OMIM COSMIC |