Basic Information
| LncRNA/CircRNA Name | SMARCC2 |
| Synonyms | NA |
| Region | GRCh38_12:56162983-56189567 |
| Ensemble | ENSG00000139613 |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | gastric cancer |
| ICD-0-3 | C16 |
| Methods | qPCR, Western blot, Luciferase reporter assay, in vitro knockdown etc. |
| Sample | cell lines (AGS, SGC-7901, MKN-45,BGC-823, HGC-27), gastric cancer tissues |
| Expression Pattern | up-regulated |
| Function Description | LncRNA SMARCC2 inhibits the expression of miR-551b-3p through binding to its mRNA response elements in gastric cancer cells. Overexpression of LncRNA SMARCC2 enhances the proliferation and migration of gastric cancer cells, while inhibition of LncRNA SMARCC2 does the opposite. TMPRSS4 is a direct target gene of miR-551b-3p. We conclude that miR-551b-3p functions as a tumour suppressor gene in gastric cancer, and its function is regulated by LncRNA SMARCC2/miR-551b-3p/TMPRSS4 axis. |
| Pubmed ID | 29337109 |
| Year | 2018 |
| Title | Molecular mechanisms of lncRNA SMARCC2/miR-551b-3p/TMPRSS4 axis in gastric cancer. |
External Links
| Links for SMARCC2 | GenBank HGNC NONCODE |
| Links for gastric cancer | OMIM COSMIC |