Basic Information
| LncRNA/CircRNA Name | SlncR1 |
| Synonyms | LINC00673, HI-LNC75, HILNC75, LUCAIR1, SLNCR, SLNCR1 |
| Region | GRCh38_17:72403322-72592804 |
| Ensemble | NA |
| Refseq | NR_036488 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | melanoma |
| ICD-0-3 | NA |
| Methods | qPCR, Flow cytometry assay, RNA pull-down assay etc. |
| Sample | cell lines (A375, HEK293T) |
| Expression Pattern | up-regulated |
| Function Description | Increased expression of this lncRNA, SLNCR1, mediates melanoma invasion through a highly conserved sequence similar to that of the lncRNA SRA1. Using a sensitive technique we term RATA (RNA-associated transcription factor array), we show that the brain-specific homeobox protein 3a (Brn3a) and the androgen receptor (AR) bind within and adjacent to SLNCR1's conserved region, respectively. SLNCR1, AR, and Brn3a are specifically required for transcriptional activation of matrix metalloproteinase 9 (MMP9) and increased melanoma invasion. |
| Pubmed ID | 27210747 |
| Year | 2016 |
| Title | The lncRNA SLNCR1 Mediates Melanoma Invasion through a Conserved SRA1-like Region. |
External Links
| Links for SlncR1 | GenBank HGNC NONCODE |
| Links for melanoma | OMIM COSMIC |