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Basic Information

Classification Information

Regulatory Mechanism		Biological Function		Clinical Application
TF		Immune		Survival
Enhancer		Apoptosis		Drug
Variant		Cell Growth		Circulating
MiRNA		EMT		Metastasis
Methylation		Coding Ability		Recurrence

Cancer&Entry Information

Cancer Name	breast cancer
ICD-0-3	C50
Methods	qPCR, in vitro knockdown
Sample	breast cancer tissues, cell lines (BT549, MDA-MB-231, MDA-MB-468, MCF7 and HCC1569)
Expression Pattern	up-regulated
Function Description	BANCR was overexpressed in BC cell lines and tissues, and could promote the clinical progression of disease, including increases in tumor size, lymph node metastasis and Tumor-Node-Metastasis stage. Furthermore, high BANCR expression was demonstrated to be associated with poor overall survival rates and early recurrence of BC in patients. Additionally, univariate and multivariate COX regression analyses identified high BANCR expression as an independent risk factor of poor prognosis of patients with BC. In addition, to verify the function of BANCR in BC cell lines, BANCR expression was silenced using short hairpin RNAs in MDA-MB-231 cells and overexpressed in MDA-MB-468 cells. An MTT assay and colony formation assay indicated that BANCR knockdown could suppress the proliferation of BC cells, whereas BANCR upregulation induced the proliferation of BC cells. Furthermore, BANCR silencing also reduced the migration and invasion of BC cells, as demonstrated via transwell migration and invasion assays. BANCR promotes BC metastasis through regulating MMP2/9 and epithelial-mesenchymal transition (EMT).
Pubmed ID	29805676
Year	2018
Title	Long Non-Coding RNA BRAF-regulated lncRNA 1 Promotes Lymph Node Invasion, Metastasis and Proliferation, and Predicts Poor Prognosis in Breast Cancer

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