Basic Information
| LncRNA/CircRNA Name | SLCO4A1-AS1 |
| Synonyms | NA |
| Region | GRCh38_20:62663019-62666724 |
| Ensemble | ENSG00000232803 |
| Refseq | NR_024470 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | autophagy | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | colorectal cancer |
| ICD-0-3 | C19.9 |
| Methods | qPCR, Western blot, Luciferase reporter assay, in vitro knockdown |
| Sample | CRC cell lines (DLD-1, SW480, HT29, SW620, HCT116, LOVO, RKO) and normal intestinal epithelial cell lines NCM460, CRC specimens and adjacent non-tumor tissues |
| Expression Pattern | up-regulated |
| Function Description | SLCO4A1-AS1 was positively associated with PARD3 expression in CRC tissues. In vitro and in vivo studies revealed that SLCO4A1-AS1 knockdown repressed cytoprotective autophagy as assayed by transmission electron microscopy (TEM), and inhibited cell proliferation by directly targeting partition-defective 3 (PARD3). Mechanistically, SLCO4A1-AS1 acted as a sponge of miR-508-3p, leading to upregulation of PARD3 and promotion of CRC cell proliferation. |
| Pubmed ID | 31308265 |
| Year | 2019 |
| Title | LncRNA SLCO4A1-AS1 promotes colorectal cancer cell proliferation by enhancing autophagy via miR-508-3p/PARD3 axis |
External Links
| Links for SLCO4A1-AS1 | GenBank HGNC NONCODE |
| Links for colorectal cancer | OMIM COSMIC |