Basic Information
| LncRNA/CircRNA Name | SLCO4A1-AS1 |
| Synonyms | NA |
| Region | GRCh38_20:62663019-62666724 |
| Ensemble | ENSG00000232803 |
| Refseq | NR_024470 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | colorectal cancer |
| ICD-0-3 | C19.9 |
| Methods | qRT-PCR, Western blotting |
| Sample | CRC tissues,CRC cell lines HT29 and SW480 |
| Expression Pattern | up-regulated |
| Function Description | We then collected CRC tissue samples and verified that SLCO4A1-AS1 is highly expressed in CRC tissues. Furthermore, SLCO4A1-AS1 was also upregulated in the CRC cell line. In situ hybridization results showed that high expression of SLCO4A1-AS1 was associated with poor prognosis in patients with CRC. Next, we found that SLCO4A1-AS1 promoted CRC cell proliferation, migration, and invasion. |
| Pubmed ID | 31853225 |
| Year | 2019 |
| Title | LncRNA SLCO4A1-AS1 Predicts Poor Prognosis and Promotes Proliferation and Metastasis via the EGFR/MAPK Pathway in Colorectal Cancer |
External Links
| Links for SLCO4A1-AS1 | GenBank HGNC NONCODE |
| Links for colorectal cancer | OMIM COSMIC |