Basic Information
| LncRNA/CircRNA Name | BORG |
| Synonyms | NA |
| Region | NA |
| Ensemble | NA |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | cytotoxic? | |
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | triple negative breast cancer |
| ICD-0-3 | C50 |
| Methods | qPCR, RNA-seq, luciferase assays, other |
| Sample | TNBC tissues and D2.OR cells and the 4T1 progression series (67NR, 4T07,and 4T1) |
| Expression Pattern | up-regulated |
| Function Description | Here we demonstrate that expression of the pro-metastatic lncRNA BORG (BMP/OP-Responsive Gene) is greatly induced within triple-negative breast cancer (TNBC) cells subjected to environmental and chemotherapeutic stresses commonly faced by TNBC cells throughout the metastatic cascade. This stress-mediated induction of BORG expression fosters the survival of TNBC cells and renders them resistant to the cytotoxic effects of doxorubicin both in vitro and in vivo. The chemoresistant traits of BORG depend upon its robust activation of the NF-?B signaling axis via a novel BORG-mediated feed-forward signaling loop, and via its ability to bind and activate RPA1. |
| Pubmed ID | 30467380 |
| Year | 2020 |
| Title | The lncRNA BORG Facilitates the Survival and Chemoresistance of Triple-Negative Breast Cancers |
External Links
| Links for BORG | GenBank HGNC NONCODE |
| Links for triple negative breast cancer | OMIM COSMIC |