Basic Information
| LncRNA/CircRNA Name | SIRT1-AS |
| Synonyms | SIRT1-AS |
| Region | NA |
| Ensemble | NA |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | hepatocellular carcinoma |
| ICD-0-3 | C22.0 |
| Methods | qPCR, RNAi, Western blot, Northern blot etc. |
| Sample | cell line (HCC-9903) |
| Expression Pattern | up-regulated |
| Function Description | SIRT1-AS overexpression promoted the proliferation of the human HCC cell lines by upregulating the SIRT1 protein level. The mechanism was that SIRT1-AS bound to SIRT1 mRNA at 3'UTR, masked the miR-29c binding site and stabilized SIRT1 mRNA. |
| Pubmed ID | 26324025 |
| Year | 2015 |
| Title | A novel mutation in SIRT1-AS leading to a decreased risk of HCC |
External Links
| Links for SIRT1-AS | GenBank HGNC NONCODE |
| Links for hepatocellular carcinoma | OMIM COSMIC |