Basic Information
| LncRNA/CircRNA Name | SFTA1P |
| Synonyms | SFTA1P, SFTPF |
| Region | GRCh38_10:10784437-10794980 |
| Ensemble | ENSG00000225383 |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | Cisplatin | |
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | lung squamous cell carcinoma |
| ICD-0-3 | C34 |
| Methods | qPCR, Western blot etc. |
| Sample | cell lines (NCl-H226, SK-MES-1, NCl-H1299, A549, A549-DDP) |
| Expression Pattern | up-regulated |
| Function Description | Here, we found that lncRNA SFTA1P (surfactant associated 1, pseudogene), highly expressed in lung, was down-regulated in LSCC tissues and could be induced upon cisplatin treatment in LSCC cells. Elevated SFTA1P induced apoptosis and enhanced the sensitivity to cisplatin of LSCC cells. We further identified that hnRNP-U (heterogeneous nuclear ribonucleoprotein U) was down-regulated in LSCCs and positively correlated with patients??poor prognosis as well as SFTA1P. Mechanistic studies revealed that SFTA1P could up-regulate hnRNP-U expression. In addition, we identified that hnRNP-U enhanced cisplatin-induced apoptosis through up-regulation of GADD45A, high expression of which was correlated with good prognosis in LSCC patients. |
| Pubmed ID | 29228625 |
| Year | 2017 |
| Title | Long noncoding RNA SFTA1P promoted apoptosis and increased cisplatin chemosensitivity via regulating the hnRNP-U-GADD45A axis in lung squamous cell carcinoma |
External Links
| Links for SFTA1P | GenBank HGNC NONCODE |
| Links for lung squamous cell carcinoma | OMIM COSMIC |