Basic Information
| LncRNA/CircRNA Name | BORG |
| Synonyms | BMP/OP-responsive gene |
| Region | NA |
| Ensemble | NA |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | carboplatin | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | colorectal cancer |
| ICD-0-3 | C19.9 |
| Methods | RT-qPCR, Western blot analysis |
| Sample | CRC tissues,Blood,HS 722.T and RKO 2 human CRC cell lines |
| Expression Pattern | up-regulated |
| Function Description | BORG expression was upregulated in CRC tissues and was inversely correlated with p53. With application of carboplatin-based treatment, the expression level of BORG was further upregulated. In CRC cells, carboplatin upregulated the expression of BORG and BORG negatively regulated p53. Under carboplatin treatment, BORG positively regulated the viability of CRC cells. |
| Pubmed ID | 31937750 |
| Year | 2020 |
| Title | Long Non-Coding RNA (lncRNA) BMP/OP-Responsive Gene (BORG) Promotes Development of Chemoresistance of Colorectal Cancer Cells to Carboplatin |
External Links
| Links for BORG | GenBank HGNC NONCODE |
| Links for colorectal cancer | OMIM COSMIC |