Basic Information
| LncRNA/CircRNA Name | SDPR-AS |
| Synonyms | NA |
| Region | NA |
| Ensemble | NA |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | renal cell carcinoma |
| ICD-0-3 | C64.9 |
| Methods | qPCR etc. |
| Sample | renal cell carcinoma tissues, cell lines (HKC, OS-RC-2, 786-O, 769-P, Caki-1, Caki-2 and ACHN) |
| Expression Pattern | down-regulated |
| Function Description | We uncovered the downregulated expressions of both lncRNA SDPR-AS and its protein-coding gene, SDPR, in RCC tissues compared to the matched normal tissues. Furthermore, SDPR-AS and SDPR expressions were positively correlated. Overexpression and knockdown experiments suggested that SDPR-AS and SDPR were coregulated in RCC cell lines. In addition, overexpression of SDPR-AS suppressed cell migration and invasion, but not cell growth. Furthermore, expression of SDPR-AS was associated with tumor differentiation and lymphatic metastasis. Kaplan-Meier survival and log-rank tests demonstrated the association of elevated expression of SDPR-AS with increased overall survival. In conclusion, our results suggest that the SDPR-AS may serve as a prognostic biomarker and therapeutic target of RCC. |
| Pubmed ID | 28790838 |
| Year | 2017 |
| Title | Downregulation of lncRNA SDPR-AS is associated with poor prognosis in renal cell carcinoma. |
External Links
| Links for SDPR-AS | GenBank HGNC NONCODE |
| Links for renal cell carcinoma | OMIM COSMIC |