Basic Information
| LncRNA/CircRNA Name | SDPR-AS |
| Synonyms | NA |
| Region | NA |
| Ensemble | NA |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | papillary thyroid cancer |
| ICD-0-3 | NA |
| Methods | qPCR, Western blot, RNAi |
| Sample | The TPC1 and BCPAP cell lines, Primary PTC samples and matched adjacent normal thyroid tissue |
| Expression Pattern | down-regulated |
| Function Description | serum deprivation response (SDPR) was significantly downregulated in PTC. RT-qPCR was performed to assess the expression of SDPR. Both loss- and gain-of-function experiments, and flow cytometry were performed to investigate the functions. SDPR was significantly downregulated in PTC. Reduced expression of SDPR was associated with larger tumor size, more serious lymph node metastasis, and advanced AJCC stage. Patients with lower SDPR expression had a shorter recurrence-free survival. SDPR expression and AJCC stage were independent predictors of poor RFS. Moreover, cell proliferation, colony formation, and migration were inhibited after SDPR overexpression, whereas knockdown of SDPR exerted an oncogenic effect. SDPR induction also initiated the mesenchymal epithelial transition, alongside suppressing AKT signaling and cyclin family expression. Apart from DNA methylation, LOC105373813, may also co-regulate SDPR expression by forming a stable hybrid with SDPR mRNA. |
| Pubmed ID | 31334828 |
| Year | 2019 |
| Title | SDPR functions as a tumor suppressor gene in papillary thyroid cancer |
External Links
| Links for SDPR-AS | GenBank HGNC NONCODE |
| Links for papillary thyroid cancer | OMIM COSMIC |