Basic Information
| LncRNA/CircRNA Name | SDPR-AS |
| Synonyms | NA |
| Region | NA |
| Ensemble | NA |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | non small cell lung cancer |
| ICD-0-3 | C34 |
| Methods | qPCR, Western blot |
| Sample | The human AC cell line H522, LCC cell line H661, SCC cell line H520, SCLC cell line NCI-H446 and normal lung epithelial cell line of BEAS-2B, Tumor tissues and paired normal lung tissues |
| Expression Pattern | down-regulated |
| Function Description | SDPR-AS was lowly expressed in NSCLC tissues and cells, but had no changes in SCLC tissues and cells. Down-regulation of SDPR-AS enhanced the proliferation, migration and invasion and inhibited apoptosis of NSCLC cells (H522, H661 and H520). Overexpression of SDPR-AS exhibited opposite effects. Moreover, SDPR was positively regulated by SDPR-AS and effects of SDPR-AS on the cell biological processes of NSCLC cells were through regulation of SDPR. Besides, the levels of p-p38 and p-ERK were significantly decreased after SDPR-AS overexpression, which were dramatically changeover by SDPR knockdownsimultaneously. Our findings indicate that SDPR-AS was lowly expressed in NSCLC cells and down-regulation of SDPR-AS may promote the malignant behaviors of NSCLC cells possible through regulating SDPR expression and involving in p38 MAPK/ERK signaling pathway. |
| Pubmed ID | 31352804 |
| Year | 2019 |
| Title | Long non-coding RNA SDPR-AS affects the development of non small cell lung cancer by regulating SDPR through p38 MAPK/ERK signals |
External Links
| Links for SDPR-AS | GenBank HGNC NONCODE |
| Links for non small cell lung cancer | OMIM COSMIC |