Basic Information
| LncRNA/CircRNA Name | SDHAP1 |
| Synonyms | NA |
| Region | NA |
| Ensemble | NA |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | Paclitaxel | |
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | ovarian cancer |
| ICD-0-3 | C56.9 |
| Methods | qPCR, Western blot etc |
| Sample | ovarian cancer tissues, cell lines(SKOV3 and Hey-8) |
| Expression Pattern | up-regulated |
| Function Description | In this study, we demonstrated that SDHAP1 was upregulated in PTX-resistant SKOV3 and Hey-8 ovarian cancer cell lines while the level of miR-4465 was down-regulated. Knocking-down SDHAP1 induced re-acquirement of chemo-sensitivity to PTX in ovarian cancer cells in vitro. Mechanically, SDHAP1 upregulated the expression of EIF4G2 by sponging miR-4465 and thus facilitated the PTX-induced apoptosis in ovarian cancer cells. |
| Pubmed ID | 32211849 |
| Year | 2020 |
| Title | LncRNA SDHAP1 Confers Paclitaxel Resistance of Ovarian Cancer by Regulating EIF4G2 Expression via miR-4465 |
External Links
| Links for SDHAP1 | GenBank HGNC NONCODE |
| Links for ovarian cancer | OMIM COSMIC |