Basic Information
| LncRNA/CircRNA Name | BOKAS |
| Synonyms | BOK-AS1, BOK-AS, BOKAS, NAToB, NCRNA00151 |
| Region | NA |
| Ensemble | NA |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | testicular cancer |
| ICD-0-3 | C62 |
| Methods | qPCR etc. |
| Sample | cell line (Hela) |
| Expression Pattern | up-regulated |
| Function Description | The mRNA expression of BOKAS was only detected in testis and certain cancer tissues but not in other normal adult tissues examined. Overexpression of BOKAS alone exhibited no significant anti- or pro-apoptotic activity but it was able to inhibit Bok-induced apoptosis in HeLa cells. Our results suggest that BOKAS may function specifically in the human testis, where it serves as an antisense molecule to regulate Bok-induced apoptosis. |
| Pubmed ID | 19287972 |
| Year | 2009 |
| Title | A natural antisense transcript, BOKAS, regulates the pro-apoptotic activity of human Bok. |
External Links
| Links for BOKAS | GenBank HGNC NONCODE |
| Links for testicular cancer | OMIM COSMIC |