Basic Information
| LncRNA/CircRNA Name | SChLAP1 |
| Synonyms | SCHLAP1, LINC00913, PCAT11, PCAT114 |
| Region | GRCh38_2:180692104-180916939 |
| Ensemble | ENSG00000281131 |
| Refseq | NR_104323 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | prostate cancer |
| ICD-0-3 | C61.9 |
| Methods | qPCR, Western blot |
| Sample | cell line (LNCaP) |
| Expression Pattern | up-regulated |
| Function Description | SChLAP1 levels were significantly higher in PCa than in BPH and healthy individuals.SAP30L-AS1 and SChLAP1 had adequate diagnostic value to distinguish PCa from controls. Two lncRNAs separately combined with prostate specific antigen (PSA) possessed a moderate ability for discrimination. SChLAP1 expression was significantly higher in patients with higher Gleason scores, and was also effective in differentiating between BPH and PCa when the concentration of PSA was in the gray zone,may lead to the identification of suitable biomarkers, with potential diagnostic utility |
| Pubmed ID | 29614511 |
| Year | 2018 |
| Title | Tumor-Derived Exosomal Long Noncoding RNAs as Promising Diagnostic Biomarkers for Prostate Cancer. |
External Links
| Links for SChLAP1 | GenBank HGNC NONCODE |
| Links for prostate cancer | OMIM COSMIC |