Basic Information
| LncRNA/CircRNA Name | SchLAH |
| Synonyms | STEAP4, STAMP2, SchLAH, TIARP, TNFAIP9 |
| Region | GRCh38_7:88270892-88306891 |
| Ensemble | ENSG00000127954 |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | hepatocellular carcinoma |
| ICD-0-3 | C22.0 |
| Methods | qPCR, RNAi, Western blot, RIP, ChIP, Cell proliferation assay etc. |
| Sample | HCC tissues, cell lines (HepG2, Hep3B, SMMC7721, Huh7) |
| Expression Pattern | down-regulated |
| Function Description | SchLAH was generally downregulated in HCC. Overexpression of SchLAH inhibited the migration and lung metastasis of HCC cells. Knockdown of SchLAH pool promoted the migration of HCC cells. RNA pull-down and RNA immunoprecipitation assays demonstrated SchLAH physically interacted with fused in sarcoma (FUS). PCR array analysis showed that RhoA and Rac1 were the downstream effector molecules of SchLAH during HCC metastasis. |
| Pubmed ID | 28196303 |
| Year | 2017 |
| Title | Long noncoding RNA SchLAH suppresses metastasis of hepatocellular carcinoma through interacting with fused in sarcoma. |
External Links
| Links for SchLAH | GenBank HGNC NONCODE |
| Links for hepatocellular carcinoma | OMIM COSMIC |