Basic Information
| LncRNA/CircRNA Name | BOKAS |
| Synonyms | BOK-AS1, BOK-AS, BOKAS, NAToB, NCRNA00151 |
| Region | NA |
| Ensemble | NA |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | esophageal squamous cell carcinoma |
| ICD-0-3 | NA |
| Methods | qPCR, Western blot, RIP etc. |
| Sample | ESCC tissues |
| Expression Pattern | up-regulated |
| Function Description | LncRNA BOKAS was up-regulated following radiation and promoted WISP1 expression and resultant radioresistance.WISP1 facilitated its own expression in response to radiation, creating a positive feedback loop and increased radioresistance. Our study revealed WISP1 as a potential target to overcome radioresistance in ESCC. |
| Pubmed ID | 25749038 |
| Year | 2015 |
| Title | Targeting WISP1 to sensitize esophageal squamous cell carcinoma to irradiation. |
External Links
| Links for BOKAS | GenBank HGNC NONCODE |
| Links for esophageal squamous cell carcinoma | OMIM COSMIC |