Basic Information
| LncRNA/CircRNA Name | SCAL1 |
| Synonyms | LUCAT1, SCAL1 |
| Region | GRCh38_5:91303029-91314402 |
| Ensemble | ENSG00000248323 |
| Refseq | NR_103548 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | lung cancer |
| ICD-0-3 | C34 |
| Methods | qPCR, Western blot, RIP etc. |
| Sample | cell lines (A549, CL1-0, CL1-5, H1975, HCC-827, NCI-H292 etc.) |
| Expression Pattern | up-regulated |
| Function Description | We found that XLOC_004924 was elevated in the airway epithelia of cigarette smokers versus nonsmokers in both of these datasets. In the first dataset, five nonsmokers were compared with six smokers. In the second study, the smokers' epithelia demonstrated a 3.9-fold increase in XLOC_004924, compared with nonsmokers. Functionally,siRNA knockdown of SCAL1 in HBE1 cells shows significant potentiation of cytotoxicity induced by CSE in vitro. Altogether, these results identify a novel and intriguing new non-coding RNA that may act downstream of NRF2 to regulate gene expression and mediate oxidative stress protection in airway epithelial cells. |
| Pubmed ID | 23672216 |
| Year | 2013 |
| Title | Characterization of a novel long noncoding RNA, SCAL1, induced by cigarette smoke and elevated in lung cancer cell lines. |
External Links
| Links for SCAL1 | GenBank HGNC NONCODE |
| Links for lung cancer | OMIM COSMIC |