Basic Information
| LncRNA/CircRNA Name | SBF2-AS1 |
| Synonyms | SET-binding factor 2-antisense RNA1 |
| Region | GRCh38_11:9758292-9811319 |
| Ensemble | ENSG00000246273 |
| Refseq | NR_036485 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | breast cancer |
| ICD-0-3 | C50 |
| Methods | RT-qPCR, Western blot analysis, Dual luciferase reporter gene assay |
| Sample | BC tissues,cell lines (MCF-7 and MDA-MB-231,MCF-10A) |
| Expression Pattern | up-regulated |
| Function Description | Reduced SBF2-AS1 and elevated miR-143 could repress the proliferation, invasion and migration via restraining RRS1 expression. Moreover, knockdown of SBF2-AS1 up-regulated miR-143 to promote the apoptosis of BC cells by downregulating RRS1, resulting in a prohibitive effect on the tumorigenesis and progression of BC. Results of in vivo experiments indicated that the inhibited SBF2-AS1 and overexpressed miR-143 could restrict BC cell proliferation and promote apoptosis, and decelerate tumor growth in xenografts. |
| Pubmed ID | 31952549 |
| Year | 2020 |
| Title | Down-regulated lncRNA SBF2-AS1 Inhibits Tumorigenesis and Progression of Breast Cancer by Sponging microRNA-143 and Repressing RRS1 |
External Links
| Links for SBF2-AS1 | GenBank HGNC NONCODE |
| Links for breast cancer | OMIM COSMIC |