Basic Information
| LncRNA/CircRNA Name | SBDSP1 |
| Synonyms | SBDSP1, SBDSP |
| Region | GRCh38_7:72829425-72836701 |
| Ensemble | ENSG00000225648 |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | colorectal cancer |
| ICD-0-3 | C19.9 |
| Methods | qPCR, RNAi, Western blot, Cell proliferation assay etc. |
| Sample | CRC tissues, cell lines (HCT116, SW620, CaCo2, HT29, SW1116, and SW480) |
| Expression Pattern | up-regulated |
| Function Description | SBDSP1 was overexpressed in CRC tissues and cells relative to corresponding normal controls. Moreover, SBDSP1 expression was significantly greater in CRCs with nodal metastasis than in primary tumors. Downregulation of SBDSP1 significantly inhibited cell proliferation, colony formation, migration, and invasion in SW480 and HCT116 cells, which was accompanied by suppression of Akt, ERK1/2, and STAT3 phosphorylation. SBDSP1-depleted cells showed a G0/G1 cell cycle arrest and deregulation of p21 and cyclin D1. In vivo studies confirmed that SBDSP1 downregulation retarded the growth of HCT116 xenogaft tumors. |
| Pubmed ID | 27890432 |
| Year | 2017 |
| Title | Silencing of long non-coding RNA SBDSP1 suppresses tumor growth and invasion in colorectal cancer. |
External Links
| Links for SBDSP1 | GenBank HGNC NONCODE |
| Links for colorectal cancer | OMIM COSMIC |