Basic Information
| LncRNA/CircRNA Name | SATB2-AS1 |
| Synonyms | SATB2-AS1 |
| Region | GRCh38_2:199457700-199476935 |
| Ensemble | ENSG00000225953 |
| Refseq | NR_026830 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | osteosarcoma |
| ICD-0-3 | NA |
| Methods | Microarray, qPCR, RNAi, Western blot, Cell proliferation assay etc. |
| Sample | osteosarcoma tissues, cell lines (U2OS, HOS, MG63, and HLF) |
| Expression Pattern | up-regulated |
| Function Description | This is the first report, where we have documented the increased expression of SATB2-AS1 in osteosarcoma patients and in human osteosarcoma cancer cell lines (U2OS, HOS, MG63). SATB2-AS1 expression was significantly higher in the metastatic tumors compared to non-metastatic tumors. In vitro gain and loss of function approaches demonstrated that SATB2-AS1 regulates cell cycle, cell proliferation, and cell growth. In addition, SATB2-AS1 affects the translational expression of SATB2 gene. |
| Pubmed ID | 28190168 |
| Year | 2017 |
| Title | A novel antisense long non-coding RNA SATB2-AS1 overexpresses in osteosarcoma and increases cell proliferation and growth. |
External Links
| Links for SATB2-AS1 | GenBank HGNC NONCODE |
| Links for osteosarcoma | OMIM COSMIC |