Basic Information
| LncRNA/CircRNA Name | BM742401 |
| Synonyms | GATA6-AS1, BM742401, locus5689 |
| Region | GRCh38_18:22166898-22168968 |
| Ensemble | ENSG00000266010 |
| Refseq | NR_102763 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | chronic lymphocytic leukemia |
| ICD-0-3 | NA |
| Methods | qPCR, MSP-PCR, Western blot, in vitro knockdown etc. |
| Sample | bone marrow, cell lines (MEC1 and CLL-AAT) |
| Expression Pattern | up-regulated |
| Function Description | The promoter of BM742401 was unmethylated in normal controls including three each of normal bone marrow, peripheral blood buffy coats, and CD19-sorted peripheral B-cells, but methylated in four (57.1%) CLL cell lines. Functionally, stable overexpression of BM742401 resulted in inhibition of cellular proliferation and enhanced apoptosis through caspase-9-dependent intrinsic but not caspase-8-dependent extrinsic apoptosis pathway, suggesting a tumor suppressor role of BM742401 in CLL. In primary CLL samples, methylation of BM742401 was detected in 43/98 (43.9%) of patients. |
| Pubmed ID | 27689399 |
| Year | 2016 |
| Title | Epigenetic silencing of tumor suppressor long non-coding RNA BM742401 in chronic lymphocytic leukemia. |
External Links
| Links for BM742401 | GenBank HGNC NONCODE |
| Links for chronic lymphocytic leukemia | OMIM COSMIC |