Basic Information
| LncRNA/CircRNA Name | SAMD12-AS1 |
| Synonyms | NA |
| Region | GRCh38_8:118621001-118858218 |
| Ensemble | ENSG00000281641 |
| Refseq | NR_038210 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | glioma |
| ICD-0-3 | NA |
| Methods | qPCR, Western blot |
| Sample | The human glioma cell lines (U251, U87, T98-G, A172) and Human brain normal glial cell line (HEB), Tumor tissue, paracancerous tissue |
| Expression Pattern | up-regulated |
| Function Description | SAMD12-AS1 expression in tumor tissue specimens of glioma patients was remarkably higher than that in the adjacent ones, and the difference was statistically significant. Compared with patients with low expression of SAMD12-AS1, patients with high expression of SAMD1-AS1 had a higher incidence of lymph node or distant metastasis. In addition, compared to the NC group, knocking down SAMD12- AS1 markedly attenuated the proliferation rate, as well as the invasiveness and migration ability of glioma cells. Subsequently, in glioma tissues, it was verified that P53 expression was remarkably decreased and negatively correlated with SAMD12-AS1. Finally, cell recovery experiment also demonstrated that there may exist a mutual regulation between SAMD12-AS1 and P53, which then together affected the malignant progression of glioma. |
| Pubmed ID | 31646576 |
| Year | 2019 |
| Title | LncRNA SAMD12-AS1 down-regulates P53 to promote malignant progression of glioma |
External Links
| Links for SAMD12-AS1 | GenBank HGNC NONCODE |
| Links for glioma | OMIM COSMIC |