Basic Information
| LncRNA/CircRNA Name | RUSC1-AS1 |
| Synonyms | NA |
| Region | GRCh38_1:155316863-155324176 |
| Ensemble | ENSG00000225855 |
| Refseq | NR_145424 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | breast cancer |
| ICD-0-3 | C50 |
| Methods | qPCR, Western blot, RIP |
| Sample | BCa cell lines (MDA-MB-231, MCF-7, BT549) and breast epithelial cell line (MCF-10A), BCa tissues and adjacent normal tissues |
| Expression Pattern | up-regulated |
| Function Description | A higher abundance of RUSC1- AS1 was identified in BCa tissues relative to controls. The expression level of RUSC1-AS1 was positively correlated to tumor size and clinical grade, but negatively correlated to the overall survival of BCa patients. The silence of RUSC1-AS1 markedly inhibited viability, clonality, cell cycle progression, and induced apoptosis of MCF-7 and BT549 cells. Finally, CDKN1A and KLF2 were found to be the target genes of RUSC1-AS1, which were tumor-suppressor genes involved in RUSC1-AS1-mediated BCa progression. |
| Pubmed ID | 31378902 |
| Year | 2019 |
| Title | LncRNA RUSC1-AS1 promotes the proliferation of breast cancer cells by epigenetic silence of KLF2 and CDKN1A |
External Links
| Links for RUSC1-AS1 | GenBank HGNC NONCODE |
| Links for breast cancer | OMIM COSMIC |