Basic Information
| LncRNA/CircRNA Name | RUNXOR |
| Synonyms | NA |
| Region | NA |
| Ensemble | NA |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | lung cancer |
| ICD-0-3 | C34 |
| Methods | qPCR, in vitro knockdown |
| Sample | lung cancer tissues, peripheral blood samples |
| Expression Pattern | up-regulated |
| Function Description | The lncRNA RUNXOR was upregulated in the peripheral blood of lung cancer patients. The RUNXOR level was remarkably correlated with smoking history (P????.039), TNM stage (P????.0001), histological tumor type (P????.016) and lymph node metastasis (P????.0028) in lung cancer. In addition, as a target gene of RUNXOR, the expression of RUNX1 was downregulated in lung cancer patients. Finally, the expression of RUNXOR was higher in MDSCs isolated from the tumor tissues of lung cancer patients compared with cells from adjacent tissue. In addition, RUNXOR knockdown decreased Arg1 expression in MDSCs. |
| Pubmed ID | 29914443 |
| Year | 2018 |
| Title | Long Non-Coding RNA RUNXOR Accelerates MDSC-mediated Immunosuppression in Lung Cancer |
External Links
| Links for RUNXOR | GenBank HGNC NONCODE |
| Links for lung cancer | OMIM COSMIC |