Basic Information
| LncRNA/CircRNA Name | Rs11655237 |
| Synonyms | Rs11655237 polymorphism of LINC00673 |
| Region | NA |
| Ensemble | NA |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | 2 | ||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | cervical cancer |
| ICD-0-3 | C53 |
| Methods | real-time PCR, luciferase assay, Western-blot analysis |
| Sample | peripheral blood and cervical lavage samples |
| Expression Pattern | up-regulated |
| Function Description | Compared with patients carrying the rs11655237 A allele of LINC00673 rs11655237 SNP, patients carrying the G allele showed higher overall survival and higher miR-1231 expression. the exosomes carrying GG, GA, and AA genotypes of LINC00673 rs11655237 SNP reduced tumor growth in mice, while the inhibitory effect of rs11655237 A allele was much stronger than that of the rs11655237 G allele. Additionally, exosome treatment upregulated the expression of LINC000673 and IFNAR1 while downregulating the expression of miR-1231. Cells transfected with exosomes carrying GG, GA, and AA genotypes of LINC00673 rs11655237 SNP achieved higher LINC000673 and IFNAR1 expression along with lower miR-1231 expression. |
| Pubmed ID | 31957869 |
| Year | 2020 |
| Title | Rs11655237 Polymorphism of LINC00673 Affects the Prognosis of Cervical Cancer by Interfering With the Interaction Between LINC00673 and microRNA-1231 |
External Links
| Links for Rs11655237 | GenBank HGNC NONCODE |
| Links for cervical cancer | OMIM COSMIC |