Basic Information
| LncRNA/CircRNA Name | RPSAP52 |
| Synonyms | NA |
| Region | NA |
| Ensemble | NA |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | pituitary adenoma |
| ICD-0-3 | C75.1 |
| Methods | qRT-PCR , Luciferase reporter assay , Western blot etc. |
| Sample | gonadotroph adenomas and normal pituitary tissues ,cancer cell lines (HT-29 ,MEG01,HCT-116 and BCPAP) |
| Expression Pattern | up-regulated |
| Function Description | RPSAP52 expression is highly upregulated in gonadotroph and prolactin-secreting pituitary adenomas, where it correlates with that of HMGA2, compared with normal pituitary tissues.RPSAP52 enhances HMGA2 protein expression in a ceRNA-dependent way acting as sponge for miR-15a, miR-15b, and miR-16, which have been already described to be able to target HMGA2.RPSAP52 promotes cell growth by enhancing the G1-S transition of the cell cycle. |
| Pubmed ID | 31076808 |
| Year | 2019 |
| Title | RPSAP52 lncRNA Is Overexpressed in Pituitary Tumors and Promotes Cell Proliferation by Acting as miRNA Sponge for HMGA Proteins |
External Links
| Links for RPSAP52 | GenBank HGNC NONCODE |
| Links for pituitary adenoma | OMIM COSMIC |