Basic Information
| LncRNA/CircRNA Name | RPPH1 |
| Synonyms | NA |
| Region | GRCh38_14:20343048-20343685 |
| Ensemble | ENSG00000277209 |
| Refseq | NR_002312 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | colorectal cancer |
| ICD-0-3 | C19.9 |
| Methods | RNA-seq |
| Sample | CRC cell lines HCT8, SW620, HT29, and human embryonic kidney 293T cells,CRC samples |
| Expression Pattern | up-regulated |
| Function Description | lncRNA RPPH1 was significantly upregulated in CRC tissues, and the RPPH1 overexpression was associated with advanced TNM stages and poor prognosis. RPPH1 was found to promote CRC metastasis in vitro and in vivo. Mechanistically, RPPH1 induced epithelial-mesenchymal transition (EMT) of CRC cells via interacting with ?-III tubulin (TUBB3) to prevent its ubiquitination. |
| Pubmed ID | 31685807 |
| Year | 2019 |
| Title | LncRNA RPPH1 Promotes Colorectal Cancer Metastasis by Interacting With TUBB3 and by Promoting Exosomes-Mediated Macrophage M2 Polarization |
External Links
| Links for RPPH1 | GenBank HGNC NONCODE |
| Links for colorectal cancer | OMIM COSMIC |