Basic Information
| LncRNA/CircRNA Name | RPLP0P2 |
| Synonyms | RPLP0P2, RPLP0L2, RPLP0_3_1146 |
| Region | GRCh38_11:61615036-61639449 |
| Ensemble | ENSG00000243742 |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | lung adenocarcinoma |
| ICD-0-3 | C34 |
| Methods | qPCR, Cell transfection, Cell migration and invasion assay etc. |
| Sample | LAD tissues, cell lines (SPCA-1, NCI-H1299, A549, NCI-H441, LTEP-a2) |
| Expression Pattern | down-regulated |
| Function Description | We found that RPLP0P2 expression was lower while LRRC10B mRNA level was higher in LAD than NT by qPCR. The expression of RPLP0P2 in lymph node metastasis of LAD group was significantly lower than LAD without lymph node metastasis group. Survival analysis showed that survival time of high expression of RPLP0P2 was significantly longer than low RPLP0P2 level in LAD patients. After RPLP0P2 was overexpressed, the proliferation rate, adhesion ability, S phase and G2/M phase cells and LRRC10B mRNA significantly reduced, while apoptosis and G0/G1 phase cells obviously increased, but migration ability and invasion did not significantly change. |
| Pubmed ID | 27460542 |
| Year | 2016 |
| Title | Low expression lncRNA RPLP0P2 is associated with poor prognosis and decreased cell proliferation and adhesion ability in lung adenocarcinoma. |
External Links
| Links for RPLP0P2 | GenBank HGNC NONCODE |
| Links for lung adenocarcinoma | OMIM COSMIC |