Basic Information
| LncRNA/CircRNA Name | RPL34-AS1 |
| Synonyms | NA |
| Region | GRCh38_4:108538190-108620460 |
| Ensemble | ENSG00000234492 |
| Refseq | NR_026968 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | esophageal cancer |
| ICD-0-3 | C15 |
| Methods | qRT-PCR etc. |
| Sample | esophageal cancer and adjacent normal tissues,esophageal cancer cell lines( TE-1, TE-13, KYSE150 and KYSE450) and normal esophageal cell line Het-1A |
| Expression Pattern | down-regulated |
| Function Description | RPL34-AS1 expression levels in esophageal cancer tissue and specimens and cell lines were lower than in adjacent normal tissue specimens and normal esophageal cell line, respectively. In addition, esophageal cancer patients with ???? T3-T4 or positive lymph node metastasis had lower RPL34-AS1expression levels than esophageal cancer patients with ???? T1-T2 or negative lymph node metastasis, respectively. In survival analysis suggested esophageal cancer patients with low RPL34-AS1 expression had short overall survival than those with high RPL34-AS1 expression. Our in vitro experiments suggested RPL34-AS1 inhibits esophageal cancer cell proliferation, migration and invasion through down-regulating RPL34 expression. |
| Pubmed ID | 31574377 |
| Year | 2019 |
| Title | RPL34-AS1 Functions as Tumor Suppressive lncRNA in Esophageal Cancer |
External Links
| Links for RPL34-AS1 | GenBank HGNC NONCODE |
| Links for esophageal cancer | OMIM COSMIC |