Basic Information
| LncRNA/CircRNA Name | RP5-884M6.1 |
| Synonyms | RP5-884M6.1 |
| Region | GRCh38_7:106775011-106795564 |
| Ensemble | NA |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | nasopharyngeal cancer |
| ICD-0-3 | C11 |
| Methods | Microarray, qPCR, RNAi etc. |
| Sample | cell lines (5-8F, 6-10B, CNE-1, CNE-2, SUNE-1, HNE-1, HONE-1 and C666-1) |
| Expression Pattern | up-regulated |
| Function Description | In order to verify the microarray data, we selected the 26 most significantly dysregulated lncRNAs, which included 15 upregulated lncRNAs and 11 downregulated lncRNAs and then validated their expression level by qRT-PCR in two sets of NPC cells.The results showed that the expression patterns of 22 lncRNAs were consistent with the microarray data. The expression level of ENST00000470135, which was the most upregulated lncRNA in high metastatic cell lines, was significantly higher in NPC cell lines and tissues with lymph node metastasis (LNM) and knocking down ENST00000470135 suppressed the migration, invasion and proliferation of NPC cells in vitro. |
| Pubmed ID | 27886062 |
| Year | 2016 |
| Title | Microarray Expression Profiling of Long Non-Coding RNAs Involved in Nasopharyngeal Carcinoma Metastasis. |
External Links
| Links for RP5-884M6.1 | GenBank HGNC NONCODE |
| Links for nasopharyngeal cancer | OMIM COSMIC |