Basic Information
| LncRNA/CircRNA Name | RP1-93H18.6 |
| Synonyms | NA |
| Region | GRCh38_6:116460739-116463692 |
| Ensemble | NA |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | cervical cancer |
| ICD-0-3 | C53 |
| Methods | qRT-PCR, Western blot analysis |
| Sample | CC and paracancerous tissues,cervical immortalized epithelial cell line END1/E6E7 and CC cell lines SiHa, HeLa, Caski, and C-33A |
| Expression Pattern | up-regulated |
| Function Description | lncRNA RP1-93H18.6 was highly expressed in CC, which could activate the P13K/Akt axis. RP1-93H18.6 vectors exposure increased cell viability, adhesion, migration, and invasion, which resulted in more cells arrested at the S stage and reduced apoptosis, while acting to promote tumor growth and metastasis. |
| Pubmed ID | 31877407 |
| Year | 2020 |
| Title | Silencing of Long Non-coding RNA RP1-93H18.6 Acts as a Tumor Suppressor in Cervical Cancer Through the Blockade of the PI3K/Akt Axis |
External Links
| Links for RP1-93H18.6 | GenBank HGNC NONCODE |
| Links for cervical cancer | OMIM COSMIC |