Basic Information
| LncRNA/CircRNA Name | RP1-85F18.6 |
| Synonyms | NA |
| Region | NA |
| Ensemble | NA |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | colorectal cancer |
| ICD-0-3 | C19.9 |
| Methods | qPCR, other |
| Sample | CRC tissues and cell lines (SW480, SW620 and HCT116) |
| Expression Pattern | up-regulated |
| Function Description | Knockdown of lncRNA RP1-85F18.6 served a key role in tumor inhibition, reduced cell proliferation and invasion, disrupted the cell cycle, and increased apoptosis and pyroptosis of CRC cells. Conversely, overexpression of lncRNA RP1-85F18.6 exerted the opposite effects. Furthermore, silencing lncRNA RP1-85F18.6 decreased ?Np63 expression at both the mRNA and protein levels. Furthermore, co-transfection with ?Np63 siRNA and lncRNA RP1-85F18.6-expressing vector attenuated the tumor-promoting effects of lncRNA RP1-85F18.6 overexpression. The expression levels of lncRNA RP1-85F18.6, ?Np63 and gasdermin D (GSDMD) were revealed to be associated with lymph node and distant metastases in patients with CRC, and therefore may serve as predictors in CRC. The findings of the present study suggested that lncRNA RP1-85F18.6 may trigger CRC cell proliferation, invasion and cell cycle disruption, and suppress apoptosis and pyroptosis of CRC cells through regulating ?Np63 expression. |
| Pubmed ID | 30226619 |
| Year | 2018 |
| Title | Biological Functions and Clinical Significance of the Newly Identified Long Non-coding RNA RP1-85F18.6 in Colorectal Cancer |
External Links
| Links for RP1-85F18.6 | GenBank HGNC NONCODE |
| Links for colorectal cancer | OMIM COSMIC |