Basic Information
| LncRNA/CircRNA Name | RP11-789C1.1 |
| Synonyms | NA |
| Region | GRCh38_4:170273919-170283079 |
| Ensemble | ENSG00000250266 |
| Refseq | NR_125889 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | gastric cancer |
| ICD-0-3 | C16 |
| Methods | qPCR, Western blot, Luciferase reporter assay, in vitro knockdown |
| Sample | gastric cancer tissues, cell lines (AGS, BGC-803, HGC-27, SGC-7901, MKN-1, MKN28, and MGC803) |
| Expression Pattern | down-regulated |
| Function Description | LncRNA RP11-789C1.1 was significantly down-regulated in GC patients and cell lines, along with the concomitant up-regulation of miR-5003. LncRNA RP11-789C1.1 suppresses the proliferation of gastric cancer cells. Silencing RP11-789C1.1 and over-expressing miR-5003 significantly promoted the tumor behavior of GC cells. Dual-luciferase reporter assays confirmed that miR-5003 was the target of both RP11-789C1.1 and E-cadherin. Furthermore, at both the mRNA and protein level, silencing RP11-789C1.1 remarkably reduced the expression of E-cadherin and promoted EMT, which were reversed by knocking down miR-5003. |
| Pubmed ID | 29991048 |
| Year | 2018 |
| Title | Long Non-Coding RNA RP11-789C1.1 Suppresses Epithelial to Mesenchymal Transition in Gastric Cancer Through the RP11-789C1.1/MiR-5003/E-Cadherin Axis |
External Links
| Links for RP11-789C1.1 | GenBank HGNC NONCODE |
| Links for gastric cancer | OMIM COSMIC |