Basic Information
| LncRNA/CircRNA Name | RP11-708H21.4 |
| Synonyms | NA |
| Region | NA |
| Ensemble | NA |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | 5-Fluorouracil (5-FU) | |
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | colorectal cancer |
| ICD-0-3 | C19.9 |
| Methods | RNA-seq, qPCR, Western blot etc. |
| Sample | colorectal cancer tissues, cell lines (DLD-1, SW-480, HT-29, SW-620, HCT-116 and LOVO) |
| Expression Pattern | up-regulated |
| Function Description | Overexpressed RP11-708H21.4 suppresses CRC cell proliferation through inducing G1 arrest. Moreover, up-regulation of RP11-708H21.4 inhibits cell migration and invasion, causes cell apoptosis, and enhances 5-FU sensitivity of CRC cells. |
| Pubmed ID | 28427191 |
| Year | 2017 |
| Title | Down-regulation of long non-coding RNA RP11-708H21.4 is associated with poor prognosis for colorectal cancer and promotes tumorigenesis through regulating AKT/mTOR pathway |
External Links
| Links for RP11-708H21.4 | GenBank HGNC NONCODE |
| Links for colorectal cancer | OMIM COSMIC |