Basic Information
| LncRNA/CircRNA Name | BLACAT1 |
| Synonyms | BLACAT1, LINC00912, UBC1, onco-lncRNA-30 |
| Region | GRCh38_1:205434886-205437879 |
| Ensemble | ENSG00000281406 |
| Refseq | NR_103783 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | gastric cancer |
| ICD-0-3 | C16 |
| Methods | qPCR, Western blot, Luciferase reporter assay, in vitro knockdown etc. |
| Sample | cell lines (BGC-823, SGC-7901, MGC-803,GES-1),gastric cancer tissue |
| Expression Pattern | up-regulated |
| Function Description | In vitro, BLACAT1 knockdown decreased the expression levels of drug resistance related genes and ABCB1 protein. BLACAT1 knockdown significantly promoted apoptosis and down-regulated the invasion and the IC50 value of oxaliplatin.In vivo, BLACAT1 knockdown suppressed the tumor growth of gastric cancer cells. Bioinformatics tools and luciferase assay indicated that miR-361 both targeted 3'-UTR of BLACAT1 and ABCB1mRNA, suggesting the BLACAT1/miR-361/ABCB1 regulatory pathway. |
| Pubmed ID | 29710482 |
| Year | 2018 |
| Title | Long noncoding RNA BLACAT1 modulates ABCB1 to promote oxaliplatin resistance of gastric cancer via sponging miR-361. |
External Links
| Links for BLACAT1 | GenBank HGNC NONCODE |
| Links for gastric cancer | OMIM COSMIC |