Basic Information
| LncRNA/CircRNA Name | RP11-480I12.5 |
| Synonyms | NA |
| Region | NA |
| Ensemble | NA |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | cervical cancer |
| ICD-0-3 | C53 |
| Methods | RT-qPCR, Western blotting |
| Sample | CC tissues,cervical epithelial ECT cell line PCS-480-011, and the human CC cell lines SiHa (HTB-35), HeLa229 (CCL-2.1) and MS751 (HTB-34),C33A (HTB-31), HeLa (CCL-2) and Caski (CRM-CRL-1550) |
| Expression Pattern | up-regulated |
| Function Description | RP11-480I12.5 was upregulated in CC tissue compared with normal tissue. Furthermore, RP11-480I12.5 was associated with clinical stage, tumor size and lymph node metastasis. RP11-480I12.5 promoted the proliferation, migration and invasion of CC cell lines.RP11-480I12.5 promoted EMT through the Wnt/?-catenin pathway. |
| Pubmed ID | 31897160 |
| Year | 2020 |
| Title | Long Non-Coding RNA RP11-480I12.5 Promotes Cervical Carcinoma Progression by Regulating the Wnt/?-catenin Signaling Pathway |
External Links
| Links for RP11-480I12.5 | GenBank HGNC NONCODE |
| Links for cervical cancer | OMIM COSMIC |