Basic Information
LncRNA/CircRNA Name | RP11-476D10.1 |
Synonyms | NA |
Region | GRCh38_12:40140926-40142876 |
Ensemble | NA |
Refseq | NA |
Classification Information
Regulatory Mechanism | Biological Function | Clinical Application | |||
---|---|---|---|---|---|
TF | Immune | Survival | |||
Enhancer | Apoptosis | autophagy/apoptosis | Drug | ||
Variant | Cell Growth | Circulating | |||
MiRNA | EMT | Metastasis | |||
Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
Cancer Name | papillary thyroid cancer |
ICD-0-3 | NA |
Methods | RT-qPCR, RIP, Western blot analysis etc. |
Sample | PTC cell line TPC-1 |
Expression Pattern | up-regulated |
Function Description | Initially, RP11-476D10.1 and LRRK2 were highly expressed in PTC cells. Meanwhile, miR-138-5p was confirmed to bind with lncRNA RP11-476D10.1 and LRRK2. RP11-476D10.1 downregulated the miR-138-5p expression, thereby upregulating the LRRK2 expression.The results showed that silenced lncRNA RP11-476D10.1 or overexpressed miR-138-5p enhanced the apoptosis and autophagy of PTC cells while reducing cell proliferation, with increased levels of Bax, LC3B, and Beclin1 and decreased Bcl-2 level were observed. |
Pubmed ID | 31102261 |
Year | 2019 |
Title | Silencing of Long Noncoding RNA RP11-476D10.1 Enhances Apoptosis and Autophagy While Inhibiting Proliferation of Papillary Thyroid Carcinoma Cells via microRNA-138-5p-dependent Inhibition of LRRK2 |
External Links
Links for RP11-476D10.1 | GenBank HGNC NONCODE |
Links for papillary thyroid cancer | OMIM COSMIC |