Basic Information
| LncRNA/CircRNA Name | BLACAT1 |
| Synonyms | NA |
| Region | GRCh38_1:205434886-205437879 |
| Ensemble | ENSG00000281406 |
| Refseq | NR_103783 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | afatinib | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | non small cell lung cancer |
| ICD-0-3 | C34 |
| Methods | qPCR, Western blot, in vitro knockdown |
| Sample | NSCLC cell lines Calu3 and H1975 |
| Expression Pattern | up-regulated |
| Function Description | BLACAT1 was up-regulated in afatinib-resistant NSCLC cells. Knockdown of BLACAT1 reversed the resistance of afatinib to NSCLC cells by modulating STAT3 signaling. The results provided a potential strategy for afatinib-resistant NSCLC by targeting BLACAT1. |
| Pubmed ID | 31359792 |
| Year | 2019 |
| Title | Knockdown of lncRNA BLACAT1 reverses the resistance of afatinib to non small cell lung cancer via modulating STAT3 signaling |
External Links
| Links for BLACAT1 | GenBank HGNC NONCODE |
| Links for non small cell lung cancer | OMIM COSMIC |