Basic Information
| LncRNA/CircRNA Name | BLACAT1 |
| Synonyms | NA |
| Region | GRCh38_1:205434886-205437879 |
| Ensemble | ENSG00000281406 |
| Refseq | NR_103783 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | steosarcoma |
| ICD-0-3 | NA |
| Methods | qPCR, Western blot, etc. |
| Sample | OS tissues, human osteosarcoma cell lines (MG-63, SAOS-2, U20S, 143B) and human normal osteoblastic cell line (hFOB1.19) |
| Expression Pattern | up-regulated |
| Function Description | BLACAT1 was upregulated in OS tissues and cells. Upregulation of BLACAT1 predicted unfavorable prognosis for patients with OS. Downregulation of BLACAT1 inhibited cell proliferation and invasion, whereas upregulation of BLACAT1 accelerated cell proliferation and invasion. More importantly, BLACAT1 could interact with STAT3 and regulat the phosphorylation of STAT3. |
| Pubmed ID | 30665678 |
| Year | 2019 |
| Title | LncRNA BLACAT1 accelerates the proliferation and migration of osteosarcoma cells through regulating STAT3. |
External Links
| Links for BLACAT1 | GenBank HGNC NONCODE |
| Links for steosarcoma | OMIM COSMIC |