Basic Information
| LncRNA/CircRNA Name | RP11-422N16.3 |
| Synonyms | NA |
| Region | GRCh38_8:109644115-109648084 |
| Ensemble | NA |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | hepatocellular carcinoma |
| ICD-0-3 | C22.0 |
| Methods | qRT-PCR, Dual Luciferase Reporter Assay, Western blot |
| Sample | hepatocellular carcinoma tissues,Hepatocellular carcinoma cell lines (HepG2, SMMC-7721, MHCC97-H, and HCCLM3) and human normal liver cell line (L02) |
| Expression Pattern | down-regulated |
| Function Description | Expressions of RP11-422N16.3 and DMGDH were down-regulated while that of miR-23b-3p were up-regulated in hepatocellular carcinoma cancer tissues and cells. RP11-422N16.3 localized in cytoplasm and competitively bound to miR-23b-3p. Up-regulation of RP11-422N16.3 and down-regulation of miR-23b-3p contributed to increased expressions of DMGDH and E-cadherin, and decreased expressions of miR-23b-3p, ZEB1, Snail and Vimentin, resulting in inhibiting cell proliferation and promoting cell apoptosis. |
| Pubmed ID | 31849497 |
| Year | 2019 |
| Title | LncRNA RP11-422N16.3 Inhibits Cell Proliferation and EMT, and Induces Apoptosis in Hepatocellular Carcinoma Cells by Sponging miR-23b-3p |
External Links
| Links for RP11-422N16.3 | GenBank HGNC NONCODE |
| Links for hepatocellular carcinoma | OMIM COSMIC |