Basic Information
| LncRNA/CircRNA Name | RP11-361F15.2 |
| Synonyms | NA |
| Region | NA |
| Ensemble | NA |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | osteosarcoma |
| ICD-0-3 | NA |
| Methods | qRT-PCR, Western blot analysis, Dual luciferase reporter assay, RIP |
| Sample | osteosarcoma tissues,human osteosarcoma cell lines MG-63, U2OS, HOS, 13B, human osteoblast cell line hFOB 1.19 and RAW264.7 cells |
| Expression Pattern | up-regulated |
| Function Description | RP11-361F15.2 is significantly increased in OS tissues, and its expression is positively correlated with cytoplasmic polyadenylation element binding protein 4 (CPEB4) expression and negatively associated with miR-30c-5p expression. Further, overexpression of RP11-361F15.2 increased OS cell migration/invasion and M2-Like polarization of TAMs in vitro, as well as promoted xenograft tumor growth in vivo. |
| Pubmed ID | 31904478 |
| Year | 2020 |
| Title | LncRNA RP11-361F15.2 Promotes Osteosarcoma Tumorigenesis by Inhibiting M2-Like Polarization of Tumor-Associated Macrophages of CPEB4 |
External Links
| Links for RP11-361F15.2 | GenBank HGNC NONCODE |
| Links for osteosarcoma | OMIM COSMIC |